Pulmonary Fibrosis and the TGF-β Signaling Axis: Advances in Targeted Therapeutics

2026/07/01 by Ying Wang, Yixin Xu, Yu Zhang +5
Medicine · Biochemistry, Genetics and Molecular Biology · #Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis #Lung Cancer Treatments and Mutations #Connective Tissue Growth Factor Research

paper · doi:10.1016/j.ejphar.2026.179174

Citations

• TGF-β1-mediated fibroblast–myofibroblast terminal differentiation—the role of smad proteins
• Is Smad3 a Major Player in Signal Transduction Pathways Leading to Fibrogenesis?
• Sequential deposition of latent TGF-β binding proteins (LTBPs) during formation of the extracellular matrix in human lung fibroblasts
• A direct interaction between TGFβ activated kinase 1 and the TGFβ type II receptor: Implications for TGFβ signalling and cardiac hypertrophy
• Role and interaction of connective tissue growth factor with transforming growth factor-? in persistent fibrosis: A mouse fibrosis model
• Latent Transforming Growth Factor-β Binding Protein Domains Involved in Activation and Transglutaminase-dependent Cross-Linking of Latent Transforming Growth Factor-β
• Transforming Growth Factor-β-Dependent Growth Inhibition in Primary Vascular Smooth Muscle Cells Is p38-Dependent
• Elongation factor-2 kinase acts downstream of p38 MAPK to regulate proliferation, apoptosis and autophagy in human lung fibroblasts
• MiR-124 regulates transforming growth factor-β1 induced differentiation of lung resident mesenchymal stem cells to myofibroblast by repressing Wnt/β-catenin signaling
• Transforming growth factor–β in tissue fibrosis
• Myricetin ameliorates bleomycin-induced pulmonary fibrosis in mice by inhibiting TGF-β signaling via targeting HSP90β
• Impact of Antifibrotic Therapy on Mortality and Acute Exacerbation in Idiopathic Pulmonary Fibrosis
• Dehydrozingerone alleviates pulmonary fibrosis via inhibition of inflammation and epithelial-mesenchymal transition by regulating the Wnt/β-catenin pathway