Sesamol, a major lignan in sesame seeds (Sesamum indicum): Anti-cancer properties and mechanisms of action

2019/05/06 by Amin F. Majdalawieh, Zeenah R. Mansour · 26 citations
Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Antioxidant #Apoptosis #Biochemistry #Biology #Cancer #Cancer cell #Chemistry #Curcumin's Biomedical Applications #Ginger and Zingiberaceae research #Internal medicine #Lignan #Medicine #Pharmacology #Sesame and Sesamin Research #Sesamol #Sesamum #Stereochemistry

paper · doi:10.1016/j.ejphar.2019.05.008

openalex publication_date 2019/05/06 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/05

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• Sesamol Increases Ucp1 Expression in White Adipose Tissues and Stimulates Energy Expenditure in High-Fat Diet-Fed Obese Mice. [europepmc]
• Integrated small RNA and Degradome sequencing provide insights into salt tolerance in sesame (Sesamum indicum L.). [europepmc]
• Sesamol Alleviates the Cytotoxic Effect of Cyclophosphamide on Normal Human Lung WI-38 Cells via Suppressing RAGE/NF-κB/Autophagy Signaling. [europepmc]
• Sesamol-Loaded PLGA Nanosuspension for Accelerating Wound Healing in Diabetic Foot Ulcer in Rats. [europepmc]
• Comparative metabolomics analysis of different sesame (Sesamum indicum L.) tissues reveals a tissue-specific accumulation of metabolites. [europepmc]
• Natural Products Counteracting Cardiotoxicity during Cancer Chemotherapy: The Special Case of Doxorubicin, a Comprehensive Review. [europepmc]
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• CRISPR/Cas9-Mediated Efficient Targeted Mutagenesis in Sesame ( Sesamum indicum L.). [europepmc]
• Development of Sesamol Carbamate-L-Phenylalanine Prodrug Targeting L-Type Amino Acid Transporter1 (LAT1) as a Potential Antiproliferative Agent against Melanoma. [europepmc]
• Formulation, Characterization, Anti-Inflammatory and Cytotoxicity Study of Sesamol-Laden Nanosponges. [europepmc]
• Sesamol Attenuates Renal Inflammation and Arrests Reactive-Oxygen-Species-Mediated IL-1β Secretion via the HO-1-Induced Inhibition of the IKKα/NFκB Pathway In Vivo and In Vitro. [europepmc]
• Development of Guar Gum Hydrogel Containing Sesamol-Loaded Nanocapsules Designed for Irritant Contact Dermatitis Treatment Induced by Croton Oil Application. [europepmc]
• The Impact of Za'atar Antioxidant Compounds on the Gut Microbiota and Gastrointestinal Disorders: Insights for Future Clinical Applications. [europepmc]
• Formulation Strategies for Enhancing Pharmaceutical and Nutraceutical Potential of Sesamol: A Natural Phenolic Bioactive. [europepmc]
• Byproducts of Sesame Oil Extraction: Composition, Function, and Comprehensive Utilization. [europepmc]
• Sesamin: A Promising Therapeutic Agent for Ameliorating Symptoms of Diabetes. [europepmc]
• In Vitro Comparative Study on Antineoplastic Effects of Pinoresinol and Lariciresinol on Healthy Cells and Breast Cancer-Derived Human Cells. [europepmc]
• Sesame Seeds: A Nutrient-Rich Superfood. [europepmc]
• The promising antioxidant effects of lignans: Nrf2 activation comes into view. [europepmc]
• 5-Fluorouracil- and Sesamol-Loaded Transliposomal Gel for Skin Cancer: In Vitro, Ex Vivo , and Dermatokinetic Evaluation. [europepmc]