2025/08/01 by Wolint, Petra, Miescher, Iris, Mechakra, Asma +7
Medicine · #610 Medicine & #Angiogenesis #Elbow and Forearm Trauma Treatment #Mesenchymal stem cells #Periodontal Regeneration and Treatments #Proteomics #Secretome #Tendon Structure and Treatment #Tendon healing #Tenocytes #health
paper · doi:10.5167/uzh-280020
openalex publication_date 2025/08/01 · openalex created_date 2025/11/23 · openalex updated_date 2026/07/28
Tendon rupture repairs exhibit two main problems. On the one hand side, they often lead to scar formation during healing, which has inferior mechanical properties and may lead to re-ruptures. On the other hand side, fibrotic adhesion formation to the surrounding tissue may occur, which hampers proper range of motion. Cell-free approaches to support tendon healing are getting increasing attention worldwide. We have therefore obtained two different cell secretomes from New Zealand White rabbit adipose tissue-derived mesenchymal stem cells (ADSCs) or from a 3:1 mixed culture of ADSCs and rabbit Achilles tenocytes. These cell secretomes were examined and compared in terms of their proteomic profiles and biological activities. Applied to a tenocyte culture, gene expression analysis data and scratch assay data are provided. To determine the angiogenic potential, the chorioallantoic membrane of the chicken embryo (CAM) was treated with the secretomes.