NFAT transcription factors in control of peripheral T cell tolerance

2006/10/14 by Edgar Serfling, Stefan Klein‐Hessling, Alois Palmetshofer +3 · 19 citations
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · #Signaling Pathways in Disease #T-cell and B-cell Immunology #Immune Cell Function and Interaction

paper · doi:10.1002/eji.200536618

Abstract

The Ca++-regulated calcineurin/NFAT cascade is one of the crucial signalling pathways that controls adaptive immunity. However, a number of novel experimental data suggest that, in addition to their role in T cell activation, NFATc transcription factors play also a decisive role in the generation of peripheral tolerance against self-antigens. This function of NFATc factors is mediated by controlling activation-induced cell death and clonal anergy of T helper cells and the activity of regulatory T cells. The multi-functional role of NFATc proteins characterize these transcription factors as key regulators of immunological tolerance and, if dysregulated, of development of autoimmune diseases.

Citations

• Retarded thymic involution and massive germinal center formation in NF-ATp-deficient mice

Cited by

• Heat shock proteins and the calcineurin-crz1 signaling regulate stress responses in fungi
• Transcriptional regulation of T cell tolerance. [europepmc]
• NFATc1 regulates PD-1 expression upon T cell activation. [europepmc]
• Interaction of calcineurin with substrates and targeting proteins. [europepmc]
• Divergent effects of calcineurin Aβ on regulatory and conventional T-cell homeostasis. [europepmc]
• ORAI1 deficiency impairs activated T cell death and enhances T cell survival. [europepmc]
• Lentivirus-activated T regulatory cells suppress T helper cell interleukin-2 production by inhibiting nuclear factor of activated T cells 2 binding to the interleukin-2 promoter. [europepmc]
• The calcineurin-NFAT axis controls allograft immunity in myeloid-derived suppressor cells through reprogramming T cell differentiation. [europepmc]
• Immunological Disorders: Regulation of Ca 2+ Signaling in T Lymphocytes. [europepmc]
• NFAT control of immune function: New Frontiers for an Abiding Trooper. [europepmc]
• B cell development is critically dependent on NFATc1 activity. [europepmc]
• The Transcription Factor NFATc1 Supports the Rejection of Heterotopic Heart Allografts. [europepmc]
• Functional Analysis of an Inducible Promoter Driven by Activation Signals from a Chimeric Antigen Receptor. [europepmc]
• Kaempferol and Its Glycoside, Kaempferol 7-O-Rhamnoside, Inhibit PD-1/PD-L1 Interaction In Vitro. [europepmc]
• Lack of NFATc1 SUMOylation prevents autoimmunity and alloreactivity. [europepmc]
• Aberrant expression of USF2 in refractory rheumatoid arthritis and its regulation of proinflammatory cytokines in Th17 cells. [europepmc]
• Isoform-Selective NFAT Inhibitor: Potential Usefulness and Development. [europepmc]
• NFAT Factors Are Dispensable for the Development but Are Critical for the Maintenance of Foxp3 + Regulatory T Cells. [europepmc]
• Hematopoietic Stem and Progenitor Cell Maintenance and Multiple Lineage Differentiation Is an Integral Function of NFATc1. [europepmc]

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