Low‐level infection with Trichuris muris significantly affects the polarization of the CD4 response

1994/12/01 by Allison J. Bancroft, Kathryn J. Else, Richard K. Grencis · 25 citations
Immunology and Microbiology · Veterinary · Environmental Science · #Parasites and Host Interactions #Helminth infection and control #Parasite Biology and Host Interactions

paper · doi:10.1002/eji.1830241230

Abstract

Resistance and susceptibility to the intestinal nematode Trichuris muris has been shown to be dependent upon the induction of T helper type 2 (Th2) or Th1 cells, respectively. This study demonstrates that in a normally resistant strain of mouse, i.e. BALB/K which mounts a dominant Th2 response, sub-threshold levels of infection (< 40 eggs) can survive and become sexually mature adult worms (10-20 adults). The immunological basis of this phenomenon was found to be a dramatically altered polarization of the CD4 response. The Th2-response characteristic of this strain of mouse infected with T. muris was shown to be significantly down-regulated as assessed by in vitro cytokine production [interleukin (IL)-4, IL-5 and IL-9]. In contrast, Th1 parameters of infection such as in vitro interferon-gamma production and the presence of parasite-specific IgG2a were greatly up-regulated in these mice.

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