Proteomic analysis of human T cell‐derived exosomes reveals differential RAS/MAPK signaling

2018/09/12 by Inbar Azoulay‐Alfaguter, Adam Mor · 20 citations
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · #Biochemistry #Biology #Cell #Cell biology #Cell signaling #Exosome #Extracellular vesicles in disease #Galectins and Cancer Biology #Gene #Immune system #Immunology #Immunotherapy and Immune Responses #MAPK/ERK pathway #Microvesicles #Signal transduction #Vesicle #microRNA

paper · doi:10.1002/eji.201847655

openalex publication_date 2018/09/12 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

Exosomes are cell-derived vesicles that have been implicated in the pathogenesis of many inflammatory diseases. More specifically, it has been shown that T cell-derived exosomes can induce immunological responses; however, little is known about the mechanism and the molecular content of these vesicles. Here, we used a proteomic approach to characterize human T cell-derived exosomes. We found that specific proteins of the RAS signaling pathway were enriched in exosomes derived from activated T cells, and that these vesicles induced ERK phosphorylation in recipient immune cells. Our findings support a mechanistic role of exosomes in cellular activation, and further studies should consider exosomes as a biomarker for inflammatory diseases.

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