IFITM3‐specific antibody reveals IFN preferences and slow IFN induction of the antiviral factor IFITM3 in humans

2020/10/30 by Dannielle Wellington, Zixi Yin, Adi Abdel‐Haq +15 · 3 citations
Immunology and Microbiology · Medicine · #Immune Cell Function and Interaction #interferon and immune responses #Cytokine Signaling Pathways and Interactions

paper · pdf · doi:10.1002/eji.202048706

Abstract

Using a specific antibody, we found that expression of the viral restriction factor IFITM3 differs across cell types within the immune compartment with higher expression in myeloid rather than lymphoid cells. IFITM3 expression was increased following IFN stimulation, mostly type I, in immune cells, with the exception of T cells.

Cited by

• Recognition of Immune Cell Markers of COVID-19 Severity with Machine Learning Methods. [europepmc]
• IFITM3 restricts virus-induced inflammatory cytokine production by limiting Nogo-B mediated TLR responses. [europepmc]
• Single-cell RNA-Seq analysis reveals cell subsets and gene signatures associated with rheumatoid arthritis disease activity. [europepmc]

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