Transcriptional regulation of early T‐cell development in the thymus

2016/01/14 by Wooseok Seo, Ichiro Taniuchi · 14 citations
Immunology and Microbiology · Biochemistry, Genetics and Molecular Biology · #T-cell and B-cell Immunology #Ubiquitin and proteasome pathways

paper · pdf · doi:10.1002/eji.201545821

Abstract

T-cell development occurs in multipotent progenitors arriving in the thymus, which provides a highly specialized microenvironment. Specification and sequential commitment processes to T cells begin in early thymic progenitors upon receiving thymus-specific environmental cues, resulting in the activation of the genetically programmed transcriptional cascade that includes turning on and off numerous transcription factors in a precise manner. Thus, early thymocyte differentiation has been an excellent model system to study cell differentiation processes. This review summarizes recent advances in our knowledge on thymic T-cell development from newly arrived multipotent T-cell progenitors to fully committed T-cell precursors, from the transcriptional regulation perspective.

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