Shannon Capacity of Signal Transduction for Multiple Independent\n Receptors

2016/04/12 by Peter J. Thomas, Thomas, Peter J., Andrew W. Eckford +1 · 1 citation
Biochemistry, Genetics and Molecular Biology · Engineering · #Advanced biosensing and bioanalysis techniques #DNA and Nucleic Acid Chemistry #FOS: Biological sciences #FOS: Computer and information sciences #Information Theory (cs.IT) #Molecular Communication and Nanonetworks #Molecular Networks (q-bio.MN)

paper · pdf · doi:10.48550/arxiv.1604.03508

openalex publication_date 2016/04/12 · openalex created_date 2022/10/02 · openalex updated_date 2026/07/28

Abstract

Cyclic adenosine monophosphate (cAMP) is considered a model system for signal\ntransduction, the mechanism by which cells exchange chemical messages. Our\nprevious work calculated the Shannon capacity of a single cAMP receptor;\nhowever, a typical cell may have thousands of receptors operating in parallel.\nIn this paper, we calculate the capacity of a cAMP signal transduction system\nwith an arbitrary number of independent, indistinguishable receptors. By\nleveraging prior results on feedback capacity for a single receptor, we show\n(somewhat unexpectedly) that the capacity is achieved by an IID input\ndistribution, and that the capacity for n receptors is n times the capacity for\na single receptor.\n

Cited by

• Communication System Design using Synthetic Photoisomerizable Azobenzene-Regulated K+(SPARK) channel

Related

• The Channel Capacity of Channelrhodopsin and Other Intensity-Driven\n Signal Transduction Receptors
• On the Capacity of Point-to-Point and Multiple-Access Molecular Communications with Ligand-Receptors
• Fundamental Limits to Cellular Sensing
• A formulation of the channel capacity of biochemical signaling cascades
• On the Capacity of Level and Type Modulation in Molecular Communication with Ligand Receptors