2025/11/03 by D O Akat’ev, Akatev, Dmitrii, Yijian Meng +9 · 1 citation
Biochemistry, Genetics and Molecular Biology · Materials Science · Physics and Astronomy · #FOS: Physical sciences #Gold and Silver Nanoparticles Synthesis and Applications #Optics (physics.optics) #Quantum Physics (quant-ph) #Spectroscopy Techniques in Biomedical and Chemical Research #Spectroscopy and Quantum Chemical Studies
paper · pdf · doi:10.48550/arxiv.2511.01430
openalex publication_date 2025/11/03 · openalex created_date 2025/11/06 · openalex updated_date 2026/07/28
Stimulated Raman scattering (SRS) microscopy has emerged as a powerful technique for probing the spatiotemporal dynamics of molecular bonds with exceptional sensitivity, resolution, and speed. However, classically, its performance remains fundamentally constrained by optical shot noise, which imposes a strict limit on detection sensitivity and speed. Here, we demonstrate a quantum-enhanced SRS microscopy platform that circumvents this barrier by harnessing amplitude-squeezed light. Specifically, we generate a Stokes beam with 5.2~dB of amplitude squeezing using traveling-wave optical parametric amplification in second-order nonlinear waveguides, and combine it with a tunable coherent pump to access vibrational modes spanning from 1000 to 3100~cm-1. Applied to quantum imaging of metabolites in biological tissue (pork muscle), our quantum-enhanced Raman microscope achieves an average noise suppression of 3.6~dB and a 51% enhancement in signal-to-noise ratio (SNR) -- to the best of our knowledge, the largest improvement reported to date in quantum-enhanced SRS microscopy of biological samples.