2024/07/30 by Hasan Berkay Abdioğlu, Yağmur Işık, Abdioglu, Hasan Berkay +15
Engineering · #3D Printing in Biomedical Research #Biological Physics (physics.bio-ph) #FOS: Physical sciences
paper · pdf · doi:10.48550/arxiv.2407.21182
openalex publication_date 2024/07/30 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Accurately measuring cell stiffness is challenging due to the invasiveness of traditional methods like atomic force microscopy (AFM) and optical stretching. We introduce a non-invasive off-axis system using holographic imaging and acoustic stimulation. This system features an off-axis Mach-Zehnder interferometer and bulk acoustic waves to capture cell mechanics. It employs high-resolution components to create detailed interferograms and allows continuous imaging of cell deformation. Unlike conventional techniques, our method provides high-throughput, label-free measurements while preserving cell integrity. Polyacrylamide beads are tested for high precision, highlighting the potential of the system in early cancer detection, disease monitoring, and mechanobiological research.