2024/03/27 by Hartwig, Andrea, MAK Commission
#(C12–C18) Alkyl alcohols #(C12–C18)-Alkylalkohole #571.95 Toxicology #571.95 Toxikologie #616.9803 Betriebs- und Arbeitsmedizin #616.9803 Industrial and occupational medicine #Atemtrakt #Emulgator #Fatty alcohols C12–18 #Fettalkohole C12–18 #Luft #Reizwirkung #Sensibilisierung #air #emulsifier #irritation #respiratory tract #sensitization
paper · doi:10.34865/mb6776225kskd9_1or
The German Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area (MAK Commission) summarized and evaluated the data for fatty alcohols C12–18 [67762-25-8] to derive an occupational exposure limit value (maximum concentration at the workplace, MAK value) considering all toxicological end points. Relevant studies were identified from a literature search. There are no data for humans or repeated dose inhalation studies in animals to derive a MAK value for the fatty alcohols C12–18. Oral studies investigating alcohols with similar chain length resulted in NOAELs which would correspond to a concentration of 92 mg/m3 or higher at the workplace. However, as the fatty alcohols C12–18 may act as non-ionic surfactants, effects on the pulmonary surfactant are likely to occur. As a result, a MAK value cannot be established. The fatty alcohols C12–18 are not mutagenic or clastogenic in vitro. No in vivo genotoxicity studies and no carcinogenicity studies have been carried out with the fatty alcohols C12–18. There are no studies investigating the developmental toxicity of the fatty alcohols C12–18. A sensitizing potential is not expected based on the available data. The substance does not penetrate the skin in toxicologically relevant amounts.