2024/09/29 by Eckert, Elisabeth, Bader, Michael, Drexler, Hans +2
#571.95 Toxicology #571.95 Toxikologie #616.9803 Betriebs- und Arbeitsmedizin #616.9803 Industrial and occupational medicine #Arbeitsstoff #Biomonitoring #Blut #Dimethylene oxide #Dimethylenoxid #EKA #Epoxyethan #Epoxyethane #Ethylene oxide #Ethylenoxid #Expositionsäquivalente für krebserzeugende Arbeitsstoffe #Gefahrstoff #N-(2-Hydroxyethyl)valin #N-(2-Hydroxyethyl)valine #Oxiran #Oxirane #Toxizität #biomonitoring #blood #exposure equivalents for carcinogenic substances #hazardous substance #occupational exposure #toxicity
paper · doi:10.34865/bb7521d9_3ad
The German Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area (MAK Commission) summarised and re-evaluated the data for the exposure equivalents for carcinogenic substances (EKA) of ethylene oxide [75-21-8]. Relevant studies were identified from a literature search. Based on the available studies on the correlation between external and internal exposure of ethylene oxide in the air and of its haemoglobin adduct N-(2-hydroxyethyl)valine (HEV), the EKA were confirmed and extended to a lower exposure range using linear extrapolation. Additionally, the adduct concentrations were converted into the internationally common unit [pmol/g globin]. Sampling time is after at least 3 months of exposure.