2025/09/09 by Elisabeth Erbes, Erbes, Elisabeth, Biswas, Naireeta +38
Biochemistry, Genetics and Molecular Biology · Materials Science · #Biological Physics (physics.bio-ph) #FOS: Physical sciences #Hydrogels: synthesis, properties, applications #Lipid Membrane Structure and Behavior #Materials Science (cond-mat.mtrl-sci) #Medical Physics (physics.med-ph) #Supramolecular Self-Assembly in Materials
paper · pdf · doi:10.48550/arxiv.2509.08019
openalex publication_date 2025/09/09 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
A novel concept of nano-scaled interwoven templates for drug delivery with alternating hydro- and lipophilicity properties is introduced. They are built from cellulose and peptide hydrogel in tandem, and characterized by a nano-stacked interwoven design, thus enabling for tuning the lipophilicity in the mesh nano-domains in which drug candidates of complementary lipophilicities can be embedded. This allows for low-dose-controlled consumption and therapeutic applications. Time-resolved and in-situ grazing incidence X-ray scattering studies confirm the design of the therapeutic nano-paper and create conditions suitable for the drug storage of complementary properties. The molecular design has the potential of a locally controlled, site-specific drug release on a beyond-nanomolar scale. Generalized, the design may contribute to facile developments of personalized medicine.