2024/12/03 by Yiqian Luo, Qiurong Chen, Luo, Yiqian +9 · 2 citations
Neuroscience · #EEG and Brain-Computer Interfaces #FOS: Biological sciences #Functional Brain Connectivity Studies #Neurons and Cognition (q-bio.NC) #Photoreceptor and optogenetics research
paper · pdf · doi:10.48550/arxiv.2412.02424
openalex publication_date 2024/12/03 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
Autism Spectrum Disorder (ASD) is a pervasive developmental disorder of the central nervous system, primarily manifesting in childhood. It is characterized by atypical and repetitive behaviors. Currently, diagnostic methods mainly rely on questionnaire surveys and behavioral observations, which are prone to misdiagnosis due to their subjective nature. With advancements in medical imaging, MR imaging-based diagnostics have emerged as a more objective alternative. In this paper, we propose a Hierarchical Neural Network model for ASD identification, termed ASD-HNet, which hierarchically extracts features from functional brain networks based on resting-state functional magnetic resonance imaging (rs-fMRI) data. This hierarchical approach enhances the extraction of brain representations, improving diagnostic accuracy and aiding in the identification of brain regions associated with ASD. Specifically, features are extracted at three levels: (1) the local region of interest (ROI) scale, (2) the community scale, and (3) the global representation scale. At the ROI scale, graph convolution is employed to transfer features between ROIs. At the community scale, functional gradients are introduced, and a K-Means clustering algorithm is applied to group ROIs with similar functional gradients into communities. Features from ROIs within the same community are then extracted to characterize the communities. At the global representation scale, we extract global features from the whole community-scale brain networks to represent the entire brain. We validate the effectiveness of our method using the publicly available Autism Brain Imaging Data Exchange I (ABIDE-I) dataset. Experimental results demonstrate that ASD-HNet outperforms existing methods. The code is available at https://github.com/LYQbyte/ASD-HNet.