2017/07/25 by Hadi Arjmandi‐Tash, Arjmandi-Tash, Hadi, Amedeo Bellunato +11
Chemistry · Engineering · #Applied Physics (physics.app-ph) #Biological Physics (physics.bio-ph) #Electrostatics and Colloid Interactions #FOS: Physical sciences #Instrumentation and Detectors (physics.ins-det) #Microfluidic and Capillary Electrophoresis Applications #Nanopore and Nanochannel Transport Studies
paper · pdf · doi:10.48550/arxiv.1707.07933
openalex publication_date 2017/07/25 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
High-fidelity analysis of translocating biomolecules through nanopores demands shortening the nanocapillary length to a minimal value. Existing nanopores and capillaries, however, inherit a finite length from the parent membranes. Here, we form nanocapillaries of zero depth by dissolving two superimposed and crossing metallic nanorods, thereby opening two overlapping nanofluidic channels molded in a polymeric resin. In an electrolyte, the interface shared by the crossing fluidic channels is mathematically of zero thickness and defines the narrowest constriction in the stream of ions through the nanopore device. This novel architecture provides the possibility to design nanopore fluidic channels, particularly with a robust 3D architecture maintaining the ultimate zero thickness geometry independently of the thickness of the fluidic channels. With orders of magnitude reduced biomolecule translocation speed, and lowered electronic and ionic noise compared to nanopores in 2D materials, our findings establish interfacial nanopores as a scalable platform for realizing nanofluidic systems, capable of single-molecule detection.