2008/03/15 by D. B. Uskov, Uskov, Dmitry B., Alexander L. Burin +1
Biochemistry, Genetics and Molecular Biology · Physics and Astronomy · #DNA and Nucleic Acid Chemistry #FOS: Physical sciences #Soft Condensed Matter (cond-mat.soft) #Spectroscopy and Quantum Chemical Studies #Surface and Thin Film Phenomena
paper · pdf · doi:10.48550/arxiv.0803.2266
openalex publication_date 2008/03/15 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Microscopic mechanisms of positive charge transfer in DNA remain unclear. A quantum state of electron hole in DNA is determined by the competition of the pi-stacking interaction b sharing a charge between different base pairs and the interaction λ with the local environment which attempts to trap charge. To determine which interaction dominates we investigated charge quantum states in various (GC)n sequences choosing DNA parameters satisfying experimental data for the balance of charge transfer rates G+ ↔ Gn+, n=2,3 \citeFredMain. We show that experimental data can be consistent with theory only assuming b≪ λ meaning that charge is typically localized within the single G site. Consequently any DNA sequence including the one consisting of identical base pairs behaves more like an insulating material then a molecular conductor. Our theory can be verified experimentally, for instance measuring balance of charge transfer reactions G+ ↔ Gn+, n ≥ 4 and comparing the experimental results with our predictions.