2009/06/19 by Hamid R. Noori, Hamid Reza Noori, Noori, Hamid Reza
Biochemistry, Genetics and Molecular Biology · #Amino Acid Enzymes and Metabolism #FOS: Biological sciences #Mitochondrial Function and Pathology #Neurons and Cognition (q-bio.NC) #Protein Structure and Dynamics #q-bio.NC
paper · pdf · doi:10.48550/arxiv.0906.3678
openalex publication_date 2009/06/19 · arxiv created 2009/09/17 · arxiv updated 2009/12/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Recent experimental studies strongly suggest the influence of glial purinergic transmission in the modulation of synaptic dynamics. By releasing adenosine triphosphate (ATP), which accumulates as adenosine, astrocytes tonically suppressed synaptic transmission. The delayed multi-step feedback of the glial adenosine with the neuron suggest the existence of hysteresis phenomena, which are investigated in the present study from the theoretical point of view. The model suggests that a memory operator, tripartite synaptic plasticity, governs the mysterious delayed feedback inhibition caused by the action of adenosine on neuronal A1 receptors and provides a powerful tool for further dynamical modeling tasks on tripartite synapses.