Quantifying phage-bacteria dynamics in vitro: rapid emergence of phage-resistant mutants for Klebsiella pneumoniae

2025/05/31 by Marcos Rodríguez, Irene Cantallops, Pilar Domingo‐Calap +1
Environmental Science · Biochemistry, Genetics and Molecular Biology · Agricultural and Biological Sciences · #Bacteriophages and microbial interactions #Evolution and Genetic Dynamics #Plant Virus Research Studies

paper · doi:10.17912/micropub.biology.001666

Abstract

alone and with the presence of bacteriophage vB_Kpn₂-P4. Using mathematical models we estimate key parameters for these experiments, showing the rapid growth and emergence of phage-resistant mutants which outcompete the susceptible bacteria strains. Our results provide quantitative estimates of these processes and may be useful for understanding phage-bacterial dynamical systems and parameterizing future theoretical and computational models.

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