2022/01/24 by Ibarra-Junquera, V., Radillo-Ochoa, D., Terrero-Escalante, C. A. · 1 citation
#37N25 #90B15 #92C37 #Biological Physics (physics.bio-ph) #Cell Behavior (q-bio.CB) #FOS: Biological sciences #FOS: Physical sciences #Subcellular Processes (q-bio.SC)
paper · doi:10.48550/arxiv.2201.10007
A theoretical study of cell evolution is presented here. By using a toolbox containing an intracellular catalytic reaction network model and a mutation-selection process, four distinct phases of self-organization were unveiled. First, the nutrients prevail as the central substrate of the chemical reactions. Second, the cell becomes a small-world. Third, a highly connected core component emerges, concurrently with the nutrient carriers becoming the central product of reactions. Finally, the cell reaches a steady configuration where the concentrations of the core chemical species are described by Zipf's law.