2014/06/10 by Emiliano Pérez Ipiña, Ipiña, Emiliano Pérez, Silvina Ponce Dawson +1 · 2 citations
Biochemistry, Genetics and Molecular Biology · Engineering · #Biological Physics (physics.bio-ph) #DNA and Nucleic Acid Chemistry #FOS: Biological sciences #FOS: Physical sciences #Gene Regulatory Network Analysis #Molecular Junctions and Nanostructures #Quantitative Methods (q-bio.QM)
paper · pdf · doi:10.48550/arxiv.1406.2724
openalex publication_date 2014/06/10 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Information transmission in cells occurs quite accurately even when\nconcentration changes are "read" by individual target molecules. In this Letter\nwe study molecule number fluctuations when molecules diffuse and react. We show\nthat, for immobile binding sites, fluctuations in the number of bound molecules\nare averaged out on a relatively fast timescale due to correlations. This\nresult can explain the observed co-existence of highly fluctuating\ninstantaneous transcriptional activities and of relatively stable protein\nconcentrations shortly after the beginning of transcription. We also show that\nbound molecule numbers fluctuate with one or two characteristic timescales\ndepending on the concentration of free molecules. This transition can explain\nchanges in enzyme activity observed at the single molecule level.\n