2000/11/29 by Ewa Gudowska–Nowak, E. Gudowska-Nowak, M. Kraemer +8
Biochemistry, Genetics and Molecular Biology · Mathematics · Physics and Astronomy · #Biological Physics (physics.bio-ph) #DNA Repair Mechanisms #Data Analysis #FOS: Biological sciences #FOS: Physical sciences #Markov Chains and Monte Carlo Methods #Quantitative Biology (q-bio) #Statistics and Probability (physics.data-an) #Stochastic processes and statistical mechanics #physics.bio-ph #physics.data-an #q-bio
paper · pdf · doi:10.48550/arxiv.physics/0011071
7 pages, 4 figures
arxiv created 2000/11/29 · openalex publication_date 2000/11/29 · arxiv updated 2009/12/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
According to the experimental evidence damage induced by densely ionizing radiation in mammalian cells is distributed along the DNA molecule in the form of clusters. The most critical constituent of DNA damage are double-strand breaks (DSBs) which are formed when the breaks occur in both DNA strands and are directly opposite or separated by only a few base pairs. The paper discusses a model of clustered DSB formation viewed in terms of compound Poisson process along with the predictive assay of the formalism in application to experimental data.