2003/01/21 by M. R. Dudek, S. Cebrat, Dudek, M. R. +11
Biochemistry, Genetics and Molecular Biology · Physics and Astronomy · #FOS: Biological sciences #FOS: Physical sciences #Quantitative Biology (q-bio) #Soft Condensed Matter (cond-mat.soft) #cond-mat.soft #q-bio
paper · pdf · doi:10.48550/arxiv.cond-mat/0301371
8 pages, 7 figures, submitted for publication
arxiv created 2003/01/21 · arxiv updated 2009/11/30
The coding sequence in DNA molecule is considered as a message to be transferred to receiver, the proteins, through a noisy information channel and each nucleotide is assigned a respective information weight. With the help of the nucleotide substitution matrix we estimated the lower bound of the amount of information carried out by nucleotides which is not subject of mutations. We used the calculated weights to reconstruct k-oligomers of genes from the Borrelia burgdorferi genome. We showed, that to this aim there is sufficient a simple rule, that the number of bits of the carried information cannot exceed some threshold value. The method introduced by us is general and applies to every genome.