2015/06/29 by M. Uddin, Uddin, M.
Engineering · Physics and Astronomy · #46N50 #46N60 #65D18 #Advanced X-ray Imaging Techniques #FOS: Physical sciences #Particle Accelerators and Free-Electron Lasers #Soft Condensed Matter (cond-mat.soft) #cond-mat.soft #msc:46N50 #msc:46N60 #msc:65D18
paper · pdf · doi:10.48550/arxiv.1506.08878
7 pages, 7 figures
openalex publication_date 2015/06/29 · arxiv created 2015/11/21 · arxiv updated 2015/11/24 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
Recovery of three-dimensional structure from single particle X-ray scattering of completely randomly oriented diffraction patterns as predicted few decades back has been real due to the advent of the new emerging X-ray Free Electron Laser (XFEL) technology. As the worlds first XFEL is in operation starting from June 2009 at SLAC National Lab at Stanford, the very first few experiments being conducted on larger objects such as viruses. Many of the important structures of nature such as helical viruses or deoxyribonucleic acids (DNA) consist of helical repetition of biological subunits. Hence development of method for reconstructing helical structure from collected XFEL data has been a top priority research. In this work we have developed a method for solving helical structure such as TMV (tobacco mosaic virus) from a set of randomly oriented simulated diffraction patterns exploiting symmetry and Fourier space constraint of the diffraction volume.