2016/11/29 by Delyan R. Hristov, Dong Ye, Hristov, Delyan R. +16
Engineering · #FOS: Physical sciences #Microfluidic and Bio-sensing Technologies #Particle Dynamics in Fluid Flows #Soft Condensed Matter (cond-mat.soft)
paper · pdf · doi:10.48550/arxiv.1611.09710
openalex publication_date 2016/11/29 · openalex created_date 2022/10/05 · openalex updated_date 2026/07/28
Comprehensive characterization of nanomaterials for medical applications is a\nchallenging and complex task due to the multitude of parameters which need to\nbe taken into consideration in a broad range of conditions. Routine methods\nsuch as dynamic light scattering or nanoparticle tracking analysis provide some\ninsight into the physicochemical properties of particle dispersions. For\nnanomedicine applications the information they supply can be of limited use.\nFor this reason, there is a need for new methodologies and instruments that can\nprovide additional data on nanoparticle properties such as their interactions\nwith surfaces. Nanophotonic force microscopy has been shown as a viable method\nfor measuring the force between surfaces and individual particles in the\nnano-size range. Here we outline a further application of this technique to\nmeasure the size of single particles and based on these measurement build the\ndistribution of a sample. We demonstrate its efficacy by comparing the size\ndistribution obtained with nanophotonic force microscopy to established\ninstruments, such as dynamic light scattering and differential centrifugal\nsedimentation. Our results were in good agreement to those observed with all\nother instruments. Furthermore, we demonstrate that the methodology developed\nin this work can be used to study complex particle mixtures and the surface\nalteration of materials. For all cases studied, we were able to obtain both the\nsize and the interaction potential of the particles with a surface in a single\nmeasurement.\n