2019/10/22 by Justen Geddes, Geddes, Justen, Jesper Mehlsen +3
Medicine · #Cardiovascular Health and Disease Prevention #Cardiovascular Syncope and Autonomic Disorders #FOS: Biological sciences #FOS: Electrical engineering #FOS: Mathematics #Heart Rate Variability and Autonomic Control #Quantitative Methods (q-bio.QM) #Signal Processing (eess.SP) #Spectral Theory (math.SP) #electronic engineering #information engineering
paper · pdf · doi:10.48550/arxiv.1910.10332
openalex publication_date 2019/10/22 · openalex created_date 2022/07/28 · openalex updated_date 2026/07/28
Objective: Postural Orthostatic Tachycardia Syndrome (POTS) is associated\nwith the onset of tachycardia upon postural change. The current diagnosis\ninvolves the measurement of heart rate (HR) and blood pressure (BP) during\nhead-up tilt (HUT) or active standing test. A positive diagnosis is made if HR\nchanges with more than 30 bpm (40 bpm in patients aged 12-19 years), ignoring\nall of the BP and most of the HR signals. This study examines 0.1 Hz\noscillations in systolic arterial blood pressure (SBP) and HR signals providing\nadditional metrics characterizing the dynamics of the baroreflex. Methods: We\nanalyze data from 28 control subjects and 28 POTS patients who underwent HUT.\nWe extract beat-to-beat HR and SBP during a 10 min interval including 5 minutes\nof baseline and 5 minutes of HUT. We employ Uniform Phase Empirical Mode\nDecomposition (UPEMD) to extract 0.1 Hz stationary modes from both signals and\nuse random forest machine learning and k-means clustering to analyze the\noutcomes. Results show that the amplitude of the 0.1 Hz oscillations is higher\nin POTS patients and that the phase response between the two signals is shorter\n(p < 0.005). Conclusion: POTS is associated with an increase in the amplitude\nof SBP and HR 0.1 Hz oscillation and a shortening of the phase between the two\nsignals. Significance: The 0.1 Hz phase response and oscillation amplitude\nmetrics provide new markers that can improve POTS diagnostic augmenting the\nexisting diagnosis protocol only analyzing the change in heart rate.\n