Reduced Insulin-like signaling restores motor and chemosensory neuron function in C. elegans expressing TDP-43, an ALS-Associated Protein

2025/08/05 by Vincent Lotesto, Cindy Voisine
Neuroscience · Medicine · #Regulation of Appetite and Obesity #Adipose Tissue and Metabolism

paper · doi:10.17912/micropub.biology.001788

Abstract

. Using well characterized behavioral assays, our data show that manipulating the ILS pathway significantly improves functionality of motor and chemosensory neurons in animals expressing hTDP-43.

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