2015/03/01 by Takahiro Wada, Yuichiro Manabe, Wada, Takahiro +9
Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · Physics and Astronomy · #Biological Physics (physics.bio-ph) #Chemistry #DNA Repair Mechanisms #Dose dependence #Dose rate #FOS: Physical sciences #Gene Regulatory Network Analysis #Internal medicine #Medical physics #Medicine #Mutation #Mutation frequency #Physics #Plant Genetic and Mutation Studies #Quantum mechanics #Statistical physics #Term (time) #physics.bio-ph
paper · pdf · doi:10.48550/arxiv.1503.00227
20 pages, 5 figures, 2 tables, submitted to Journal of Nuclear Science and Technology
openalex publication_date 2015/03/01 · arxiv created 2016/02/12 · arxiv updated 2016/02/15 · openalex created_date 2016/06/24 · openalex updated_date 2026/07/28
We investigate the dose and dose-rate dependence of the mutation frequency caused by artificial radiations with Whack-A-Mole (WAM) model which we have recently proposed. In particular, we pay special attention to the case of long-term and low dose-rate exposure. The results indicate that the dose-rate dependence is successfully described with WAM model and it may replace the so-called DDREF, the concept of which has long been adopted to take account of the difference between the high dose-rate data and the low dose-rate ones. Basic properties of WAM model are discussed emphasizing the dose-rate dependence to demonstrate how the explicit dose-rate dependence built in the model plays a key role. By adopting the parameters that are determined to fit the mega mouse experiments, biological effects of long-term exposure to extremely low dose-rate radiation are discussed. In WAM model, the effects of the long-term exposure show a saturation property, which makes a clear distinction from the LNT hypothesis which predicts a linear increase of the effects with time.