Lazertinib: First Approval
2021/05/24 by Sohita Dhillon · 25 citations
Medicine · Chemistry · #Lung Cancer Treatments and Mutations #Lung Cancer Research Studies #Quinazolinone synthesis and applications
paper · pdf · doi:10.1007/s40265-021-01533-x
Abstract
) is an oral, third-generation, epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) being developed by Yuhan and Janssen Biotech for the treatment of non-small cell lung cancer (NSCLC). It is a brain-penetrant, irreversible EGFR-TKI that targets the T790M mutation and activating EGFR mutations Ex19del and L858R, while sparing wild type-EGFR. In January 2021, lazertinib received its first approval for the treatment of patients with EGFR T790M mutation-positive locally advanced or metastatic NSCLC who have previously received EGFR-TKI therapy. This article summarizes the milestones in the development of lazertinib leading to this first approval.
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