2010/10/03 by Michael W. Deem, Deem, Michael W., Pooya Hejazi +1
Biochemistry, Genetics and Molecular Biology · Medicine · #FOS: Biological sciences #Influenza Virus Research Studies #Populations and Evolution (q-bio.PE) #Viral Infections and Outbreaks Research #q-bio.PE #vaccines and immunoinformatics approaches
paper · pdf · doi:10.48550/arxiv.1010.0413
49 pages, 12 figures, to appear in Annual Reviews
arxiv created 2010/10/03 · openalex publication_date 2010/10/03 · arxiv updated 2010/10/05 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
The immune system recognizes a myriad of invading pathogens and their toxic products. It does so with a finite repertoire of antibodies and T cell receptors. We here describe theories that quantify the immune system dynamics. We describe how the immune system recognizes antigens by searching the large space of receptor molecules. We consider in some detail the theories that quantify the immune response to influenza and dengue fever. We review theoretical descriptions of the complementary evolution of pathogens that occurs in response to immune system pressure. Methods including bioinformatics, molecular simulation, random energy models, and quantum field theory contribute to a theoretical understanding of aspects of immunity.