Methylglyoxal impairs endothelial insulin sensitivity both in vitro and in vivo

2014/04/23 by Cecilia Nigro, Gregory Alexander Raciti, Gregory A. Raciti +14 · 27 citations
Biochemistry, Genetics and Molecular Biology · Nursing · Medicine · #Advanced Glycation End Products research #Fatty Acid Research and Health #Chronic Kidney Disease and Diabetes

paper · doi:10.1007/s00125-014-3243-7

Cited by

• Methylglyoxal in Metabolic Disorders: Facts, Myths, and Promises
• The role of methylglyoxal and the glyoxalase system in diabetes and other age-related diseases
• Is vitamin D deficiency related to accumulation of advanced glycation end products, markers of inflammation, and oxidative stress in diabetic subjects? [europepmc]
• Dicarbonyl stress in clinical obesity. [europepmc]
• Dicarbonyls and glyoxalase in disease mechanisms and clinical therapeutics. [europepmc]
• The GLP-1 receptor agonists exenatide and liraglutide activate Glucose transport by an AMPK-dependent mechanism. [europepmc]
• Methylglyoxal-Glyoxalase 1 Balance: The Root of Vascular Damage. [europepmc]
• Dicarbonyl stress and glyoxalase enzyme system regulation in human skeletal muscle. [europepmc]
• miR-214-Dependent Increase of PHLPP2 Levels Mediates the Impairment of Insulin-Stimulated Akt Activation in Mouse Aortic Endothelial Cells Exposed to Methylglyoxal. [europepmc]
• The Destiny of Glucose from a MicroRNA Perspective. [europepmc]
• Cellular Stresses and Stress Responses in the Pathogenesis of Insulin Resistance. [europepmc]
• Ameliorating Methylglyoxal-Induced Progenitor Cell Dysfunction for Tissue Repair in Diabetes. [europepmc]
• Methylglyoxal triggers human aortic endothelial cell dysfunction via modulation of the K ATP /MAPK pathway. [europepmc]
• The combination of loss of glyoxalase1 and obesity results in hyperglycemia. [europepmc]
• Dicarbonyl Stress at the Crossroads of Healthy and Unhealthy Aging. [europepmc]
• The Role of microRNAs in Metabolic Syndrome-Related Oxidative Stress. [europepmc]
• An Unrecognized Hazard in E-Cigarette Vapor: Preliminary Quantification of Methylglyoxal Formation from Propylene Glycol in E-Cigarettes. [europepmc]
• Methylglyoxal induces p53 activation and inhibits mTORC1 in human umbilical vein endothelial cells. [europepmc]
• Role of RAGE in obesity-induced adipose tissue inflammation and insulin resistance. [europepmc]
• Diabetes and Cognitive Impairment: A Role for Glucotoxicity and Dopaminergic Dysfunction. [europepmc]
• Metformin prevents methylglyoxal-induced apoptosis by suppressing oxidative stress in vitro and in vivo. [europepmc]
• Methylglyoxal Scavengers Attenuate Angiogenesis Dysfunction Induced by Methylglyoxal and Oxygen-Glucose Deprivation. [europepmc]
• RAGE displays sex-specific differences in obesity-induced adipose tissue insulin resistance. [europepmc]
• Blood and Tissue Advanced Glycation End Products as Determinants of Cardiometabolic Disorders Focusing on Human Studies. [europepmc]
• Methylglyoxal in Cardiometabolic Disorders: Routes Leading to Pathology Counterbalanced by Treatment Strategies. [europepmc]
• A Comprehensive Review of Metabolic Dysfunction-Associated Steatotic Liver Disease: Its Mechanistic Development Focusing on Methylglyoxal and Counterbalancing Treatment Strategies. [europepmc]
• Does Gut Microbial Methylglyoxal Metabolism Impact Human Physiology? [europepmc]