Moderate exercise ameliorates dysregulated hippocampal glycometabolism and memory function in a rat model of type 2 diabetes

2016/12/07 by Takeru Shima, Takashi Matsui, Subrina Jesmin +8 · 25 citations
Neuroscience · #Memory and Neural Mechanisms #Neurogenesis and neuroplasticity mechanisms #Regulation of Appetite and Obesity

paper · pdf · doi:10.1007/s00125-016-4164-4

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• Exercise-Linked Irisin: Consequences on Mental and Cardiovascular Health in Type 2 Diabetes. [europepmc]
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• Lactate Is Answerable for Brain Function and Treating Brain Diseases: Energy Substrates and Signal Molecule. [europepmc]
• The potential mechanisms of lactate in mediating exercise-enhanced cognitive function: a dual role as an energy supply substrate and a signaling molecule. [europepmc]
• Behavioral defects and downregulation of hippocampal BDNF and nNOS expression in db/db mice did not improved by chronic TGF-β2 treatment. [europepmc]
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• Brain metabolism in Alzheimer's disease: biological mechanisms of exercise. [europepmc]
• Metformin Protects Rat Skeletal Muscle from Physical Exercise-Induced Injury. [europepmc]
• The function of previously unappreciated exerkines secreted by muscle in regulation of neurodegenerative diseases. [europepmc]
• Aerobic exercise training improves memory function through modulation of brain-derived neurotrophic factor and synaptic proteins in the hippocampus and prefrontal cortex of type 2 diabetic rats. [europepmc]
• Resistance training boosts lactate transporters and synaptic proteins in insulin-resistance mice. [europepmc]
• Lactate metabolism and histone lactylation in the central nervous system disorders: impacts and molecular mechanisms. [europepmc]
• Light-exercise-induced dopaminergic and noradrenergic stimulation in the dorsal hippocampus: Using a rat physiological exercise model. [europepmc]
• Muscle-Derived miR-200a-3p Through Light-Intensity Exercise May Contribute to Improve Memory Dysfunction in Type 2 Diabetic Mice. [europepmc]
• The Impact of Exercise Training on the Brain and Cognition in Type 2 Diabetes, and its Physiological Mediators: A Systematic Review. [europepmc]
• Aerobic exercise alleviates cognitive impairment in T2DM mice through gut microbiota. [europepmc]
• Electroacupuncture ameliorates cognitive dysfunction in T2DM rats by modulating astrocytic polarization and aberrant energy metabolism in the hippocampus via the Wnt/β-catenin pathway. [europepmc]
• Crosstalk between skeletal muscle and the brain during physical activity - in search of epigenetic mechanisms. [europepmc]