2005/01/13 by Peter F. Arndt, Arndt, Peter F., Terence Hwa +1 · 3 citations
Biochemistry, Genetics and Molecular Biology · #Epigenetics and DNA Methylation #FOS: Biological sciences #Genomics (q-bio.GN) #RNA and protein synthesis mechanisms #RNA modifications and cancer #q-bio.GN
paper · pdf · doi:10.48550/arxiv.q-bio/0501018
15 pages, 3 figures
arxiv created 2005/01/13 · openalex publication_date 2005/01/13 · arxiv updated 2009/12/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
The presence of neighbor dependencies generated a specific pattern of dinucleotide frequencies in all organisms. Especially, the CpG-methylation-deamination process is the predominant substitution process in vertebrates and needs to be incorporated into a more realistic model for nucleotide substitutions. Based on a general framework of nucleotide substitutions we develop a method that is able to identify the most relevant neighbor dependent substitution processes, measure their strength, and judge their importance to be included into the modeling. Starting from a model for neighbor independent nucleotide substitution we successively add neighbor dependent substitution processes in the order of their ability to increase the likelihood of the model describing given data. The analysis of neighbor dependent nucleotide substitutions in human, zebrafish and fruit fly is presented. A web server to perform the presented analysis is publicly available.