Smad4 is required to regulate the fate of cranial neural crest cells

2007/10/05 by Seung O Ko, Seung O. Ko, Il Hyuk Chung +6 · 25 citations
Biochemistry, Genetics and Molecular Biology · #dental development and anomalies #TGF-β signaling in diseases #Hedgehog Signaling Pathway Studies

paper · doi:10.1016/j.ydbio.2007.09.050

Cited by

• Disruption of Smad4 in neural crest cells leads to mid-gestation death with pharyngeal arch, craniofacial and cardiac defects. [europepmc]
• Ectodermal Smad4 and p38 MAPK are functionally redundant in mediating TGF-beta/BMP signaling during tooth and palate development. [europepmc]
• Homozygous missense N629D hERG (KCNH2) potassium channel mutation causes developmental defects in the right ventricle and its outflow tract and embryonic lethality. [europepmc]
• Epithelial-specific requirement of FGFR2 signaling during tooth and palate development. [europepmc]
• Stem cell property of postmigratory cranial neural crest cells and their utility in alveolar bone regeneration and tooth development. [europepmc]
• Twisted gastrulation limits apoptosis in the distal region of the mandibular arch in mice. [europepmc]
• Prx1 and Prx2 cooperatively regulate the morphogenesis of the medial region of the mandibular process. [europepmc]
• Neural crest cell-specific deletion of Rac1 results in defective cell-matrix interactions and severe craniofacial and cardiovascular malformations. [europepmc]
• Trigenic neural crest-restricted Smad7 over-expression results in congenital craniofacial and cardiovascular defects. [europepmc]
• Palate morphogenesis: current understanding and future directions. [europepmc]
• Cell autonomous requirement of endocardial Smad4 during atrioventricular cushion development in mouse embryos. [europepmc]
• The mechanism of TGF-β signaling during palate development. [europepmc]
• Redundant and dosage sensitive requirements for Fgf3 and Fgf10 in cardiovascular development. [europepmc]
• A TGFβ-Smad4-Fgf6 signaling cascade controls myogenic differentiation and myoblast fusion during tongue development. [europepmc]
• Current perspectives of the signaling pathways directing neural crest induction. [europepmc]
• Roles of BMP signaling pathway in lip and palate development. [europepmc]
• Cleft palate defect of Dlx1/2-/- mutant mice is caused by lack of vertical outgrowth in the posterior palate. [europepmc]
• Inactivation of Tgfbr2 in Osterix-Cre expressing dental mesenchyme disrupts molar root formation. [europepmc]
• BMP-SHH signaling network controls epithelial stem cell fate via regulation of its niche in the developing tooth. [europepmc]
• BMP Signaling Regulates Bone Morphogenesis in Zebrafish through Promoting Osteoblast Function as Assessed by Their Nitric Oxide Production. [europepmc]
• Dosage analysis of the 7q11.23 Williams region identifies BAZ1B as a major human gene patterning the modern human face and underlying self-domestication. [europepmc]
• BMP Signaling in the Development and Regeneration of Cranium Bones and Maintenance of Calvarial Stem Cells. [europepmc]
• Genetics and signaling mechanisms of orofacial clefts. [europepmc]
• Gene regulatory network from cranial neural crest cells to osteoblast differentiation and calvarial bone development. [europepmc]
• Tooth number abnormality: from bench to bedside. [europepmc]