Loss of uterine EGR2 contributes to age-associated decline in fertility in female mice.

2025/09/15 by Sudikshya Paudel, Magdalina J Cummings, Steven L. Young +1
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Medicine · #Hypothalamic control of reproductive hormones #Reproductive System and Pregnancy #TGF-β signaling in diseases

paper · doi:10.17912/micropub.biology.001852

openalex publication_date 2025/09/15 · openalex created_date 2025/11/14 · openalex updated_date 2026/07/01

Abstract

-deficient mouse uteri, models of reproductive aging. Conditional uterine deletion of EGR2 caused mild subfertility, with fewer litters and total pups per female. These findings indicate EGR2 supports, but is not essential for, uterine function.

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