2015/08/19 by Kisuk Lee, Lee, Kisuk, Aleksandar Zlateski +5
Biochemistry, Genetics and Molecular Biology · Computer Science · Materials Science · #Advanced Electron Microscopy Techniques and Applications #Advanced Neural Network Applications #Cell Image Analysis Techniques #Computer Vision and Pattern Recognition (cs.CV) #Electron and X-Ray Spectroscopy Techniques #FOS: Computer and information sciences #cs.CV
paper · pdf · doi:10.48550/arxiv.1508.04843
openalex publication_date 2015/08/19 · arxiv created 2015/08/20 · arxiv updated 2015/08/21 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Efforts to automate the reconstruction of neural circuits from 3D electron microscopic (EM) brain images are critical for the field of connectomics. An important computation for reconstruction is the detection of neuronal boundaries. Images acquired by serial section EM, a leading 3D EM technique, are highly anisotropic, with inferior quality along the third dimension. For such images, the 2D max-pooling convolutional network has set the standard for performance at boundary detection. Here we achieve a substantial gain in accuracy through three innovations. Following the trend towards deeper networks for object recognition, we use a much deeper network than previously employed for boundary detection. Second, we incorporate 3D as well as 2D filters, to enable computations that use 3D context. Finally, we adopt a recursively trained architecture in which a first network generates a preliminary boundary map that is provided as input along with the original image to a second network that generates a final boundary map. Backpropagation training is accelerated by ZNN, a new implementation of 3D convolutional networks that uses multicore CPU parallelism for speed. Our hybrid 2D-3D architecture could be more generally applicable to other types of anisotropic 3D images, including video, and our recursive framework for any image labeling problem.