2019/07/17 by Martin, Osvaldo A., Vila, Jorge A.
#Biomolecules (q-bio.BM) #FOS: Biological sciences #Populations and Evolution (q-bio.PE)
paper · doi:10.48550/arxiv.1907.07524
Here we propose that the upper bound marginal stability of proteins (7.4 kcal/mol) is a universal property that includes macro-molecular complexes and is not affected by molecular changes such as mutations and Post-Translational Modifications. Its existence is, essentially, a consequence of the Anfinsen thermodynamic hypothesis rather than a result of an evolutive process. This result enables us to conjecture that neutral evolution should also be, with respect to protein stability, a universal phenomenon.