Carcinogenic metals – Determination of arsenic, beryllium, cadmium, cobalt, nickel and their particulate compounds in workplace air using inductively coupled plasma mass spectrometry (ICP-MS)

2024/06/27 by Pitzke, Katrin, Brock, Thomas Helmut, Hebisch, Ralph +2
#543 Analytical chemistry #543 Analytische Chemie #571.95 Toxicology #571.95 Toxikologie #616.9803 Betriebs- und Arbeitsmedizin #616.9803 Industrial and occupational medicine #AG Analytik #Acid digestion #Analysenmethode #Arbeitsplatzmessung #Arsen #Arsen(III)oxid #Arseneous anhydride #Arsenic #Arsenic sesquioxide #Arsenic trioxide #Arsenic(III) oxide #Arsenigsäureanhydrid #Arsenik #Arsentrioxid #Beryllium #Beryllium oxide #Beryllium(II) oxide #Beryllium(II)oxid #Berylliumoxid #Bestimmungsgrenze #Cadmium #Cobalt #DGUV #DGUV Information 213-585 #Deutsche Gesetzliche Unfallversicherung #Diarsentrioxid #FSP sampler #FSP-Sammler #GSP sampler #GSP-Sammler #Gefahrstoff #German Social Accident Insurance #ICP-MS #Inductively coupled plasma mass spectrometry #Luft #Luftanalysen #Massenspektrometrie mit induktiv gekoppeltem Plasma #Membranfilter #Messbereich #Methode 01 #Nickel #Probenahme #Präzision #Selektivität #Säureaufschluss #White arsenic #Wiederfindung #air #air analyses #alveolengängige Staubfraktion #analytical method #carcinogenic metals #einatembare Staubfraktion #hazardous substance #inhalable dust faction #internal standard #interner Standard #krebserzeugende Metalle #limit of quantification #measurement range #membrane filter #method 01 #precision #recovery #respirable dust fraction #sampling #selectivity #working group analytics #workplace measurement

paper · doi:10.34865/am744038e9_2or

Abstract

This analytical method is a validated measurement procedure for the determination of arsenic [7440-38-2], beryllium [7440-41-7], cadmium [7440-43-9], cobalt [7440-48-4], nickel [7440-02-0] and their particulate compounds after personal or stationary sampling. Sampling is performed by drawing a defined volume of air through a nitrocellulose membrane filter using a suitable flow-regulated pump. After acid digestion, the elements retained on the filter are analysed using inductively coupled plasma mass spectrometry. The relative limits of quantification are between 0.00029 µg/m3 for beryllium and 0.11 µg/m3 for nickel for an air sample volume of 1.2 m3. The mean recovery was between 97% for arsenic and 111% for beryllium. The concentration-dependent expanded uncertainty was 21% to 28%. This analytical method has been accredited by the accident insurance companies for the detection in workplace air of substances that are carcinogenic, mutagenic or toxic to reproduction. This method has been tested and recommended for the determination of arsenic in work areas by the German Social Accident Insurance (DGUV). Both personal and stationary sampling can be performed for measurements in order to evaluate work areas.

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