2025/10/07 by Albert Jang, Jang, Albert, Hyungseok Jang +7
Materials Science · Physics and Astronomy · #FOS: Physical sciences #Magnetic Properties of Alloys #Magnetic and transport properties of perovskites and related materials #Magnetic properties of thin films #Medical Physics (physics.med-ph)
paper · pdf · doi:10.48550/arxiv.2510.06022
openalex publication_date 2025/10/07 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
We propose a signal acquisition and modeling framework for multi-component tissue quantification that encompasses transmit field inhomogeneity, multi-component relaxation and magnetization transfer (MT) effects. By applying off-resonance irradiation between excitation and acquisition within an RF-spoiled gradient-echo scheme, in combination with multiple echo-time acquisitions, both Bloch-Siegert shift and magnetization transfer effects are simultaneously induced while relaxation and spin exchange processes occur concurrently. Simulation results showed excellent agreement with the derived analytical signal equation across a wide range of flip angles and echo times. Monte Carlo analyses further validated that the three-pool parameter estimation pipeline performed robustly over various signal-to-noise ratio conditions. Multi-parameter fitting results from in vivo brain and knee studies yielded values consistent with previously reported literature. Collectively, these findings confirm that the proposed method can reliably characterize multi-component tissue parameters in macromolecule-rich environments while effectively compensating for B1+ inhomogeneity.