2021/01/01 by Raj Kumar Sadhu, Samo Penič, Sadhu, Raj Kumar +5 · 1 citation
Biochemistry, Genetics and Molecular Biology · Physics and Astronomy · #Biological Physics (physics.bio-ph) #Cell Behavior (q-bio.CB) #Cellular Mechanics and Interactions #FOS: Biological sciences #FOS: Physical sciences #Micro and Nano Robotics #Microtubule and mitosis dynamics #Soft Condensed Matter (cond-mat.soft)
paper · pdf · doi:10.48550/arxiv.2101.00313
openalex publication_date 2021/01/01 · openalex created_date 2022/07/25 · openalex updated_date 2026/07/28
Eukaryotic cells adhere to extracellular matrix during the normal development\nof the organism, forming static adhesion as well as during cell motility. We\nstudy this process by considering a simplified coarse-grained model of a\nvesicle that has uniform adhesion energy with a flat substrate, mobile curved\nmembrane proteins and active forces. We find that a high concentration of\ncurved proteins alone increases the spreading of the vesicle, by the\nself-organization of the curved proteins at the high curvature\nvesicle-substrate contact line, thereby reducing the bending energy penalty at\nthe vesicle rim. This is most significant in the regime of low bare\nvesicle-substrate adhesion. When these curved proteins induce protrusive\nforces, representing the actin cytoskeleton, we find efficient spreading, in\nthe form of sheet-like lamellipodia. Finally, the same mechanism of spreading\nis found to include a minimal set of ingredients needed to give rise to motile\nphenotypes.\n