2023/08/22 by Jixian Wang, Hongtao Zhang, Wang, Jixian +3
Mathematics · #Statistical Methods and Inference #Statistical Methods in Clinical Trials
paper · pdf · doi:10.48550/arxiv.2308.11374
To use historical controls for indirect comparison with single-arm trials, the population difference between data sources should be adjusted to reduce confounding bias. The adjustment is more difficult for time-to-event data with a cure fraction. We propose different adjustment approaches based on pseudo observations and calibration weighting by entropy balancing. We show a simple way to obtain the pseudo observations for the cure rate and propose a simple weighted estimator based on them. Estimation of the survival function in presence of a cure fraction is also considered. Simulations are conducted to examine the proposed approaches. An application to a breast cancer study is presented.