Parametric modeling of mechanical effects on circadian oscillators

2023/06/24 by Keith E. Kennedy, Kennedy, Keith E., Juan F. Abenza +9
Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · #Cell Behavior (q-bio.CB) #FOS: Biological sciences #Light effects on plants #Magnetic and Electromagnetic Effects #Plant and Biological Electrophysiology Studies

paper · pdf · doi:10.48550/arxiv.2306.14005

openalex publication_date 2023/06/24 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Abstract

Circadian rhythms are archetypical examples of nonlinear oscillations. While these oscillations are usually attributed to circuits of biochemical interactions among clock genes and proteins, recent experimental studies reveal that they are also affected by the cell's mechanical environment. Here we extend a standard biochemical model of circadian rhythmicity to include mechanical effects in a parametric manner. Using experimental observations to constrain the model, we suggest specific ways in which the mechanical signal might affect the clock. Additionally, a bifurcation analysis of the system predicts that these mechanical signals need to be within an optimal range for circadian oscillations to occur.

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