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Computational Modeling of an MRI Guided Drug Delivery System Based on Magnetic Nanoparticle Aggregations for the Navigation of Paramagnetic Nanocapsules

2015/04/14 by Nikolaos Lampropoulos, Lampropoulos, N. K., Evangelos Karvelas +3
Engineering · Physics and Astronomy · #Characterization and Applications of Magnetic Nanoparticles #Computational Engineering #FOS: Computer and information sciences #FOS: Physical sciences #Finance #Micro and Nano Robotics #Microfluidic and Bio-sensing Technologies #Soft Condensed Matter (cond-mat.soft) #and Science (cs.CE)

paper · pdf · doi:10.48550/arxiv.1504.03490

openalex publication_date 2015/04/14 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Abstract

A computational method for magnetically guided drug delivery is presented and the results are compared for the aggregation process of magnetic particles within a fluid environment. The model is developed for the simulation of the aggregation patterns of magnetic nanoparticles under the influence of MRI magnetic coils. A novel approach for the calculation of the drag coefficient of aggregates is presented. The comparison against experimental and numerical results from the literature is showed that the proposed method predicts well the aggregations in respect to their size and pattern dependance, on the concentration and the strength of the magnetic field, as well as their velocity when particles are driven through the fluid by magnetic gradients.

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