2012/10/09 by Aaron Santos, W. Klein, Santos, Aaron +2
Biochemistry, Genetics and Molecular Biology · Physics and Astronomy · #Biological Physics (physics.bio-ph) #Biomolecules (q-bio.BM) #DNA and Nucleic Acid Chemistry #FOS: Biological sciences #FOS: Physical sciences #Soft Condensed Matter (cond-mat.soft) #Statistical Mechanics (cond-mat.stat-mech) #cond-mat.soft #cond-mat.stat-mech #physics.bio-ph #q-bio.BM
paper · pdf · doi:10.48550/arxiv.1210.2749
18 pages, 17 figures
openalex publication_date 2012/10/09 · arxiv created 2013/03/28 · arxiv updated 2013/03/29 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
We investigate kinetic pathways of the DNA melting transition using variable-range versions of the Poland-Scheraga (PS) and Peyrard-Dauxois-Bishop (PDB) models of DNA. In the PS model, we construct a phi4-field theory to calculate the critical droplet profile, the initial growth modes, and the exponent characterizing the divergence of the susceptibility near the spinodal. In the PDB model, we use a mean field analysis to calculate susceptibility exponent. We compare these theoretical results with Monte Carlo and Brownian dynamic simulations on the PS and PDB models, respectively. We find that by increasing the range of interaction, the system can be brought close to a pseudospinodal, and that in this region the nucleating droplet is diffuse in contrast to the compact droplets predicted by classical nucleation theory.