Repurposing glucagon-like peptide-1 receptor agonists for the treatment of neurodegenerative disorders

2025/12/19 by Marwan N. Sabbagh, Jeffrey L. Cummings, Clive Ballard +9 · 1 voice · 3 citations
Medicine · Neuroscience · Biochemistry, Genetics and Molecular Biology · #Diabetes Treatment and Management #Neuropeptides and Animal Physiology #Advanced Glycation End Products research

paper · doi:10.1038/s43587-025-01029-3

Citations

• Newer glucose‐lowering drugs and risk of dementia: A systematic review and meta‐analysis of observational studies

Cited by

• Dietary Fiber and Glucagon-Like Peptide-1 Receptor Agonists in Obesity Management: Converging Mechanisms, Interactions, and Strategies for Durable Weight Control. [europepmc]
• Glucagon-Like Peptide-1 Receptor Agonists Inhibit the Initiation of Toxic Amyloid-β42 Aggregation. [europepmc]
• Lipid Metabolism Reprogramming in the Aging Brain: Glial-Mediated Pathogenic Mechanisms and Translational Strategies in Neurodegeneration [europepmc]

Discussions

• The value of the "Gliptins" more specifically, dual action Tirzepatide will have a role in Long C-19. There's a reason the Scripps Institute chose it. doi.org/10.1038/s435... [bsky, 27 points, 2 comments]