2013/12/16 by Kevin Smith, K. Smith, Brian P. Griffin +11
Biochemistry, Genetics and Molecular Biology · Physics and Astronomy · #Advanced Thermodynamics and Statistical Mechanics #Biological Physics (physics.bio-ph) #FOS: Physical sciences #Microtubule and mitosis dynamics #Protein Structure and Dynamics #physics.bio-ph
paper · pdf · doi:10.48550/arxiv.1312.4213
openalex publication_date 2013/12/16 · arxiv created 2015/01/20 · arxiv updated 2015/01/21 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
We present direct measurements of fluctuations in the nucleus of yeast cells. While prior work has shown these fluctuations to be active and non-thermal in character, their origin and time dependence are not understood. We show that the nuclear fluctuations we observe are quantitatively consistent with uncorrelated, active force fluctuations driving a nuclear medium that is dominated by an uncondensed DNA solution, for which we perform rheological measurements on an \it in vitro model system under similar conditions to what is expected in the nucleus.