2011/04/11 by Hilbert, Lennart
#Adaptation and Self-Organizing Systems (nlin.AO) #Biological Physics (physics.bio-ph) #FOS: Biological sciences #FOS: Physical sciences #Populations and Evolution (q-bio.PE)
paper · doi:10.48550/arxiv.1104.1930
Background: Acceleration of adaptation dynamics by stress-induced hypermutation has been found experimentally. Evolved evolvability is a prominent explanation. We investigate a more generally applicable explanation by a physical constraint. Methods and Results: A generic thermodynamical analysis of genetic information storage obviates physical constraints on the integrity of genetic information. The capability to employ metabolic resources is found as a major determinant of mutation probability in stored genetic information. Incorporation into a non-recombinant, asexual adaptation toy model predicts cases of markedly accelerated adaptation, driven by a transient increase of mutation rate. No change in the mutation rate as a genetic trait is required. The mutation rate of one and the same genotype varies dependent on stress level. Implications: Stress-dependent mutation rates are physically necessary and challenge a condition-independent genotype to mutation rate mapping. This holds implications for evolutionary theory and pathogen and cancer evolution.