2007/04/29 by M. Ya. Azbel, Azbel, Mark Ya.
Biochemistry, Genetics and Molecular Biology · #Adaptation and Self-Organizing Systems (nlin.AO) #Evolution and Genetic Dynamics #FOS: Biological sciences #FOS: Physical sciences #Genomics (q-bio.GN) #Genomics and Phylogenetic Studies #Other Condensed Matter (cond-mat.other) #Other Quantitative Biology (q-bio.OT) #Populations and Evolution (q-bio.PE) #Quantitative Methods (q-bio.QM) #RNA and protein synthesis mechanisms
paper · pdf · doi:10.48550/arxiv.0704.3826
openalex publication_date 2007/04/29 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Significant fraction (98.5% in humans) of most animal genomes is non- coding dark matter. Its largely unknown function (1-5) is related to programming (rather than to spontaneous mutations) of accurate adaptation to rapidly changing environment. Programmed adaptation to the same universal law for non-competing animals from anaerobic yeast to human is revealed in the study of their extensively quantified mortality (6-21). Adaptation of animals with removed non-coding DNA fractions may specify their contribution to genomic programming. Emergence of new adaptation programs and their (non-Mendelian) heredity may be studied in antibiotic mini-extinctions (22-24). On a large evolutionary scale rapid universal adaptation was vital for survival, and evolved, in otherwise lethal for diverse species major mass extinctions (25-28). Evolutionary and experimental data corroborate these conclusions (6-21, 29-32). Universal law implies certain biological universality of diverse species, thus quantifies applicability of animal models to humans). Genomic adaptation programming calls for unusual approach to its study and implies unanticipated perspectives, in particular, directed biological changes.