2007/05/14 by John Jack, Jack, John, Andrei Păun +1
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Medicine · #Cell death mechanisms and regulation #FOS: Biological sciences #HIV Research and Treatment #Hepatitis B Virus Studies #Molecular Networks (q-bio.MN) #Subcellular Processes (q-bio.SC)
paper · pdf · doi:10.48550/arxiv.0705.2032
openalex publication_date 2007/05/14 · openalex created_date 2016/06/24 · openalex updated_date 2026/07/28
We report a first in modeling and simulation of the effects of the HIV proteins on the (caspase dependent) apoptotic pathway in infected cells. This work is novel and is an extension on the recent reports and clarifications on the FAS apoptotic pathway from the literature. We have gathered most of the reaction rates and initial conditions from the literature, the rest of the constants have been computed by fitting our model to the experimental results reported. Using the model obtained we have then run the simulations for the infected memory T cells, called also latent T cells, which, at the moment, represent the major obstacle to finding a cure for HIV. We can now report that the infected latent T cells have an estimated lifetime of about 42 hours from the moment they are re-activated. As far as we know this is the first result of this type obtained for the infected memory T cells.