Global genetic interaction network of a human cell maps conserved principles and informs functional interpretation of gene co-essentiality profiles

2026/04/27 by Maximilian Billmann, Michael Costanzo, Xiang Zhang +93 · 1 voice
Biochemistry, Genetics and Molecular Biology · #Bioinformatics and Genomic Networks #Gene #Gene Regulatory Network Analysis #Gene interaction #Gene mapping #Gene regulatory network #Human cell #Human genetics #Human genome #Interpretation (philosophy) #Single-cell and spatial transcriptomics

paper · doi:10.1016/j.cell.2026.03.044

openalex publication_date 2026/04/27 · openalex created_date 2026/04/28 · openalex updated_date 2026/08/05

Discussions

• "In this study, we present a genome-scale map of genetic interactions in the human haploid cell line HAP1, based on CRISPR-based perturbation of ∼4 million gene pairs. The resulting network comprises [bsky, 29 points, 0 comments]